What happens when two of the most powerful entities in Equestria develop a condition towards each other where their magic interacts and causes them some 'unusual' problems and social embarrassment? Hilarity and a great deal of conflict, of course!
Between Luna's awkwardness with the modern world, Twilight's naievety and OCD, Discord trying to be a 'good' friend, Celestia's maternal instincts going into overdrive, the rest of the Mane Six trying to 'help' in their own special ways and the Ponies of Equestria trying to milk the situation for all it's worth, it's going to be a doozy.
A few things to consider: In this setting, Twilight is an immortal Alicorn, as is Cadence. They WILL outlive their friends/spouses without Age spells being thrown into the Mix as referenced by Trixie with her Alicorn Amulet.
Set at the end of Season 3, when Twilight first becomes an Alicorn.
Warnings: Contains Sexual Situations, occasional Gender-Swapping, the dreaded 'Futa' in a few very rare situations, 'cheating', TwilightXLuna, DiscordXCelestia, ChrysalisXShiningXCadence and other relationships that I won't spoil here.