The Great and Powerful Trixie meets up with Twilight Sparkle by chance, and things seem to be going good between the two ponies. They manage to shake off any bad memories they had of each other, and what seems like a beautiful friendship starts to form between them.
However, by some twist of fate, Trixie happens to stumble upon a suspicios stallion in black clothing performing some kind of blackmail transaction, and doesn't notice his accomplice sneaking up behind her before it's too late.
After being forced to take a strange drug that was meant to kill her, Trixie awakes to find herself a little filly again, and with the help of her friend Doctor Whooves, she keeps her identity a secret whilst hunting down the stallions in black, for fear that being found out may put her and anypony connected to her at risk.