Friendship is a very strange concept. As far as Equestria goes, friendship has often been weaponized by the Main Six to vanquish their enemies.
However, when the map acts up once more and alerts Twilight alone to another problem, it comes as a bit of a shock when her Cutie Mark leads her to the portal to the Human World, instead of a certain fragment of Equestria. Regardless, she heeds the map's call and enters the portal.
What she doesn't know that waiting in the Human World, is a threat that could very well be her undoing...